Siege of Caffa
1346 CE.
Shown on the map at 45.033°, 35.367°.
The siege of Caffa was a 14th-century military encounter when Jani Beg of the Golden Horde besieged the city of Caffa (modern-day Feodosia), between two periods in the 1340s. The city of Caffa, a Genoese colony, was a vital trading hub located in Crimea. The city was then part of Gazaria, a group of seven ports located in Crimea and belonging to the maritime empire of the Republic of Genoa. The event is historically significant primarily because it is believed to be one of the earliest instances of biological warfare. The siege of Caffa was characterized by intense military tactics from both sides. After several years of siege, the armies of the Horde were forced to withdraw. The siege is famous for a story recounted by Italian notary Gabriel de Mussis, which attributed the subsequent spread of the Black Death to plague-infested corpses having been launched over the walls at the end of the siege.
Text from the Wikipedia article Siege of Caffa, licensed CC BY-SA 4.0.