Siege of Mytilene
1464 CE.
Shown on the map at 39.112°, 26.562°.
The Siege of Mytilene was a military attempt by the Republic of Venice to capture the Island of Lesbos from the Ottomans. The Venetians made two attempts but were repelled, suffering heavy losses.
Text from the Wikipedia article Siege of Mytilene (1464), licensed CC BY-SA 4.0.