Sack of Brescia
1512 CE.
Shown on the map at 45.533°, 10.233°.
The Sack of Brescia took place on 18 February 1512, during the War of the League of Cambrai. It resulted in the massacre of the entire garrison and thousands of civilians.
Text from the Wikipedia article Sack of Brescia, licensed CC BY-SA 4.0.