The 1521–22 papal conclave elected Pope Adrian VI to succeed Pope Leo X. The conclave was marked by the early candidacies of cardinal-nephew Giulio de'Medici (future Pope Clement VII) and Alessandro Farnese (future Pope Paul III), although the Colonna and other cardinals blocked their election.
Adrian, the viceroy to Spain and a clear pro-Imperial candidate, was elected as a compromise candidate despite his absence from the conclave. The number of cardinal-electors (thirty-nine) and the length of the sede vacante increased the cost of the conclave even in excess of the funds distributed by Charles V, Holy Roman Emperor, Francis I of France, and Henry VIII of England to promote their candidates.
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