The Siege of Genoa (1522) took place in May 1522 as part of a larger conflict known as the Italian War of 1521–1526. Between 20 and 30 May 1522, the city of Genoa, defended by a French garrison, was besieged by imperial troops commanded by condottieri Prospero Colonna and Fernando Francesco d'Avalos. The siege ended with an Imperial victory, and since the city had not surrendered but rather been taken by assault, the Imperial troops were allowed to sack the city after its conquest..
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