The siege of Nice occurred in 1543 and was part of the Italian War of 1542–46 in which Francis I and Suleiman the Magnificent collaborated as part of the Franco-Ottoman alliance against the Holy Roman Emperor Charles V, and Henry VIII of England. At that time, Nice was under the control of Charles III, Duke of Savoy, an ally of Charles V.
The siege was part of the 1543–1544 Mediterranean campaign of Hayreddin Barbarossa. A Franco-Ottoman army besieged Nice, breaching the walls and conquering sections of the city, but ultimately retired before taking the citadel due to the arrival of a Imperial-Savoyard relief fleet under Andrea Doria. Nice remained thus in Savoyard hands.
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