The 1545–1546 Siege of Kawagoe Castle (河越城の戦い, Kawagoe-jyō no tatakai) was part of a failed attempt by the Uesugi clan to regain Kawagoe Castle from the Later Hōjō clan in the Sengoku period of Japan.
Uesugi Tomosada of the Ogigayatsu branch of the Uesugi clan attacking Kawagoe castle, he was joined by his more powerful relative Uesugi Norimasa from Yamanouchi branch Uesugi clan, who held the post of Kantō Kanrei, the shōgun's deputy in the Kantō region by Ashikaga Haruuji, the Kantō kubō in Koga, and by a host of anti-Hōjō daimyō from the Kantō region.
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