The siege of Fort Wayne took place from September 5–12, 1812, during the War of 1812. The stand-off occurred in the modern city of Fort Wayne, Indiana, between the U.S. military garrison at Fort Wayne and a combined force of Potawatomi and Miami forces. The conflict began when warriors under the Potawatomi chiefs Winamac and Five Medals killed two members of the U.S. garrison. Over the next several days, the Potawatomi burned the buildings and crops of the fort's adjacent village and launched assaults from outside the fort. Winamac withdrew on September 12 ahead of reinforcements led by Major General William Henry Harrison.
The attack on Fort Wayne was one of several Potawatomi attacks on U.S. military outposts during September 1812. Other coordinated attacks included Fort Dearborn, Fort Harrison, Pigeon Roost, and Fort Madison.
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