The Iglesia de la Compañía de Jesús Fire (8 December 1863) was a mass casualty event in Santiago, Chile. It is the deadliest fire known to have occurred in the city, one of the deadliest single-building fires in world history and one of the deadliest-ever fires within a religious site. Between 2,000 and 3,000 people died, most of whom were women.
The fire originated at the start of a mass being held to celebrate the Feast of the Immaculate Conception. The tragedy led directly to the establishment of the city's first organized firefighter companies, which, since then, have been staffed by volunteers.
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