The COVID-19 pandemic was confirmed to have reached the U.S. state of North Carolina on March 22, 2020.
As of May 2021, North Carolina has the 10th highest number of confirmed cases in the United States.
As of October 6, 2021, 69% of the adult population in North Carolina has been at least partially vaccinated, while 65% of the adult population has been fully vaccinated.
As of January 2026, the North Carolina Department of Health and Human Services (NCDHHS) utilizes an integrated "Respiratory Virus Surveillance Dashboard" that monitors COVID-19, influenza, and RSV together. For the week ending January 17, 2026, NCDHHS reported that while COVID-19 activity was stable, influenza-related deaths saw a significant seasonal increase, bringing the total to 134 for the 2025–26 season.
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