Battle of Barbalissos
252 CE.
Shown on the map at 36.061°, 37.891°.
The Battle of Barbalissos was fought between the Sasanians and Romans at Barbalissos. Shapur I used Roman incursions into Armenia as pretext and resumed hostilities with the Romans. The Sasanians attacked a Roman force of 60,000 strong at Barbalissos and the Roman army was destroyed. The defeat of this large Roman force left the Roman east open to attack and led to the eventual capture of Antioch and Dura Europos three years later. This battle is only known through Shapur I's inscription at Naqsh-e Rostam.
Text from the Wikipedia article Battle of Barbalissos, licensed CC BY-SA 4.0.