Siege of Antioch
260 CE.
Shown on the map at 36.200°, 36.150°.
The siege of Antioch was a battle fought between the Sasanian Empire and the Roman Empire in 260 AD. In this battle, Shapur I first besieged the city and was able to conquer Antioch for the second time by penetrating the city wals.
Text from the Wikipedia article Siege of Antioch (260), licensed CC BY-SA 4.0.