Siege of Caesarea
260 CE.
Shown on the map at 38.733°, 35.483°.
The siege of Caesarea by the Sasanians under Shapur I took place following their siege of the Roman city of Antioch in 260 which followed their major victory over the Romans in the Battle of Edessa.
Text from the Wikipedia article Siege of Caesarea in Cappadocia (260), licensed CC BY-SA 4.0.