Siege of Maiozamalcha
363 CE.
Shown on the map at 33.094°, 44.581°.
During the siege of Maiozamalcha (or Maogamalcha), 8 May 363 CE, the Roman army under Emperor Julian stormed, pillaged, and destroyed the city of Maiozamalcha, before continuing onward to the Sasanian capital of Ctesiphon.
Text from the Wikipedia article Siege of Maiozamalcha, licensed CC BY-SA 4.0.