Mesomedes of Crete (Ancient Greek: Μεσομήδης ὁ Κρής) was a Greek citharode and lyric poet and composer of the early 2nd century AD in Roman Greece. Prior to the discovery of the Seikilos epitaph in the late 19th century, the hymns of Mesomedes were the only surviving written music from the ancient world. Three were published by Vincenzo Galilei in his Dialogo della musica antica e della moderna (Florence, 1581), during a period of intense investigation into music of the ancient Greeks. These hymns had been preserved through the Byzantine tradition (Anthol. pal. xiv. 63, xvi. 323), and were presented to Vincenzo by Girolamo Mei.
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