Pier Antonio Mezzastris (or Pierantonio Mezastris; c. 1430 – c. 1506) was an Italian painter of the Quattrocento, painting in a somewhat provincial style for the time.
He was born at Foligno in Umbria. He painted religious subjects, working mostly in fresco, and was a local painter, in that all of his known works can be found within 15 km (10 mi) of his hometown, except for two frescoes in Narni. Though his subjects are very limited, his work is good, marked by technical ability and polish combined with elegance and delicacy of feeling. He is described as a follower of Benozzo Gozzoli. He should not be confused with Bernardino Mezzastris, a much lesser artist, possibly his son. His sister, Onofria, married Matteo da Gualdo, a painter from Foligno and active in Ancona and Norcia.
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