Lorenzo Leonbruno (10 March 1489 – 1537), also known as Lorenzo de Leombeni, was an Italian painter during the early Renaissance period. He was born in Mantua (Mantova), an Italian commune in Lombardy, Italy. Leonbruno is most well known for being commissioned by the court of Francesco Gonzaga, Marquis of Mantua, and his wife Isabella d'Este. The patronage continued with their eldest son Federico II Gonzaga, who was the fifth Marquis of Mantua. Leonbruno was the court painter for the Gonzaga family from 1506–24.
Leonbruno's most significant artistic commission was his decoration of the Camera Grande in the Gonzaga palace in Mantua, which was completed in 1523 for his patron Isabella d'Este.
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