Fray Domingo de Santo Tomás, O.P. (1499 – December 1570) was a Spanish Dominican missionary, bishop, and grammarian in the Viceroyalty of Peru. He compiled the first Quechua language grammar and dictionary, both published in 1560.
His grammar contained also the earliest known Quechua written text, as a catechetic appendix, and the first known linguistic description of clusivity.
A critic of Spanish treatment of the indigenous in Peru, he has been described as "greatest spokesman for native interests in Peru".
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