Khayr al-Nisa Begum (Persian: خیرالنساء بیگم; known under the royal title Mahd-i Ulya (مهد علیا), "the highest-ranked cradle"; died 26 July 1579) was an Iranian Mazandarani princess from the Marashi dynasty, who was the wife of the Safavid shah (king) Mohammad Khodabanda (r. 1578–1587) and mother of Abbas I. During the early part of her husband's reign, she was a powerful political figure in her own right and governed Iran de facto between February 1578 and July 1579. She gained power with the assassination of Pari Khan Khanum.
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