Shimon Sakaguchi (坂口 志文, Sakaguchi Shimon; born 19 January 1951) is a Japanese immunologist. He is a distinguished professor at Osaka University and a professor emeritus at Kyoto University.
His work includes the discovery of regulatory T cells and describing their role in the immune system. In 2025, he was jointly awarded the Nobel Prize in Physiology or Medicine with Mary E. Brunkow and Fred Ramsdell.
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